![Gain-of-Function Mutations: An Emerging Advantage for Cancer Biology: Trends in Biochemical Sciences Gain-of-Function Mutations: An Emerging Advantage for Cancer Biology: Trends in Biochemical Sciences](https://www.cell.com/cms/attachment/315cb52f-5c97-4624-ae1e-c6ed7be6859b/gr4.jpg)
Gain-of-Function Mutations: An Emerging Advantage for Cancer Biology: Trends in Biochemical Sciences
![Gain-of-function research can't deliver pandemic predictions. Are there alternatives? - Bulletin of the Atomic Scientists Gain-of-function research can't deliver pandemic predictions. Are there alternatives? - Bulletin of the Atomic Scientists](https://thebulletin.org/wp-content/uploads/2022/06/Escher-Pathogen-.png)
Gain-of-function research can't deliver pandemic predictions. Are there alternatives? - Bulletin of the Atomic Scientists
![Autosomal dominant retinitis pigmentosa with toxic gain of function: Mechanisms and therapeutics - Ishwarya Narasimhan, Aishwarya Murali, Krishnakumar Subramanian, Sivaprakash Ramalingam, Sowmya Parameswaran, 2021 Autosomal dominant retinitis pigmentosa with toxic gain of function: Mechanisms and therapeutics - Ishwarya Narasimhan, Aishwarya Murali, Krishnakumar Subramanian, Sivaprakash Ramalingam, Sowmya Parameswaran, 2021](https://journals.sagepub.com/cms/10.1177/1120672120957605/asset/images/large/10.1177_1120672120957605-fig1.jpeg)
Autosomal dominant retinitis pigmentosa with toxic gain of function: Mechanisms and therapeutics - Ishwarya Narasimhan, Aishwarya Murali, Krishnakumar Subramanian, Sivaprakash Ramalingam, Sowmya Parameswaran, 2021
![FamilieSCN2A on X: "What is Gain of Function (GoF) and Loss of Function (LoF)? #SCN2Afacts #SCN2A https://t.co/0Fz0DRUCkh" / X FamilieSCN2A on X: "What is Gain of Function (GoF) and Loss of Function (LoF)? #SCN2Afacts #SCN2A https://t.co/0Fz0DRUCkh" / X](https://pbs.twimg.com/media/FMDnVIDXsAAInbM.jpg)
FamilieSCN2A on X: "What is Gain of Function (GoF) and Loss of Function (LoF)? #SCN2Afacts #SCN2A https://t.co/0Fz0DRUCkh" / X
![Mechanisms conferring protein loss and toxic gain-of-function effects.... | Download Scientific Diagram Mechanisms conferring protein loss and toxic gain-of-function effects.... | Download Scientific Diagram](https://www.researchgate.net/publication/272486318/figure/fig2/AS:294829096488971@1447304142936/Mechanisms-conferring-protein-loss-and-toxic-gain-of-function-effects-The-diagram.png)
Mechanisms conferring protein loss and toxic gain-of-function effects.... | Download Scientific Diagram
![Potential Risks and Benefits of Gain-of-Function Research: Summary of a Workshop: National Research Council, Institute of Medicine, Board on Health Sciences Policy, Policy and Global Affairs, Committee on Science, Technology, and Law, Potential Risks and Benefits of Gain-of-Function Research: Summary of a Workshop: National Research Council, Institute of Medicine, Board on Health Sciences Policy, Policy and Global Affairs, Committee on Science, Technology, and Law,](https://m.media-amazon.com/images/I/914Ss2EUr0L._AC_UF1000,1000_QL80_.jpg)
Potential Risks and Benefits of Gain-of-Function Research: Summary of a Workshop: National Research Council, Institute of Medicine, Board on Health Sciences Policy, Policy and Global Affairs, Committee on Science, Technology, and Law,
![Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation: Molecular Cell Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation: Molecular Cell](https://www.cell.com/cms/attachment/30c8ff00-8bd2-44a7-b2e0-0120e2197322/fx1_lrg.jpg)
Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation: Molecular Cell
Gain-of-Function Research: Summary of the Second Symposium, March 10-11, 2016 | The National Academies Press
![Gain-of-Function Research: Balancing Science and Security | Hopkins Bloomberg Public Health Magazine Gain-of-Function Research: Balancing Science and Security | Hopkins Bloomberg Public Health Magazine](https://magazine.jhsph.edu/sites/default/files/styles/feature_image_1200_1x_/public/GainOfFunction_3200x1600%20%281%29.jpg?itok=eJt9HK67)
Gain-of-Function Research: Balancing Science and Security | Hopkins Bloomberg Public Health Magazine
![Frontiers | Mutant p53 Gain-of-Function: Role in Cancer Development, Progression, and Therapeutic Approaches Frontiers | Mutant p53 Gain-of-Function: Role in Cancer Development, Progression, and Therapeutic Approaches](https://www.frontiersin.org/files/Articles/607670/fcell-08-607670-HTML/image_m/fcell-08-607670-g005.jpg)
Frontiers | Mutant p53 Gain-of-Function: Role in Cancer Development, Progression, and Therapeutic Approaches
![STING Gain-of-Function Disrupts Lymph Node Organogenesis and Innate Lymphoid Cell Development in Mice - ScienceDirect STING Gain-of-Function Disrupts Lymph Node Organogenesis and Innate Lymphoid Cell Development in Mice - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2211124720307518-fx1.jpg)
STING Gain-of-Function Disrupts Lymph Node Organogenesis and Innate Lymphoid Cell Development in Mice - ScienceDirect
![Loss-of-function genetic diseases and the concept of pharmaceutical targets | Orphanet Journal of Rare Diseases | Full Text Loss-of-function genetic diseases and the concept of pharmaceutical targets | Orphanet Journal of Rare Diseases | Full Text](https://media.springernature.com/full/springer-static/image/art%3A10.1186%2F1750-1172-2-30/MediaObjects/13023_2007_Article_81_Fig3_HTML.jpg)
Loss-of-function genetic diseases and the concept of pharmaceutical targets | Orphanet Journal of Rare Diseases | Full Text
![The non-essentiality of essential genes suggests a loss-of-function therapeutic strategy for loss-of-function human diseases | bioRxiv The non-essentiality of essential genes suggests a loss-of-function therapeutic strategy for loss-of-function human diseases | bioRxiv](https://www.biorxiv.org/content/biorxiv/early/2016/02/22/040568/F1.large.jpg)
The non-essentiality of essential genes suggests a loss-of-function therapeutic strategy for loss-of-function human diseases | bioRxiv
![From studies in loss-of-function and gain-of-function mouse models,... | Download Scientific Diagram From studies in loss-of-function and gain-of-function mouse models,... | Download Scientific Diagram](https://www.researchgate.net/publication/236193907/figure/fig2/AS:203011063324677@1425413017274/From-studies-in-loss-of-function-and-gain-of-function-mouse-models-Stat3-has-been-shown.png)
From studies in loss-of-function and gain-of-function mouse models,... | Download Scientific Diagram
![An example of gain-of-function mutation. Most of the gene mutations... | Download Scientific Diagram An example of gain-of-function mutation. Most of the gene mutations... | Download Scientific Diagram](https://www.researchgate.net/publication/284278090/figure/fig3/AS:324906882486281@1454475245465/An-example-of-gain-of-function-mutation-Most-of-the-gene-mutations-identified-in.png)
An example of gain-of-function mutation. Most of the gene mutations... | Download Scientific Diagram
![Frontiers | Mutant p53 Gain-of-Function: Role in Cancer Development, Progression, and Therapeutic Approaches Frontiers | Mutant p53 Gain-of-Function: Role in Cancer Development, Progression, and Therapeutic Approaches](https://www.frontiersin.org/files/Articles/607670/fcell-08-607670-HTML/image_m/fcell-08-607670-g002.jpg)
Frontiers | Mutant p53 Gain-of-Function: Role in Cancer Development, Progression, and Therapeutic Approaches
![Gain-of-Function Mutations: An Emerging Advantage for Cancer Biology: Trends in Biochemical Sciences Gain-of-Function Mutations: An Emerging Advantage for Cancer Biology: Trends in Biochemical Sciences](https://www.cell.com/cms/attachment/22b4925b-b677-4a37-9d14-7b2ca802d0e2/gr2_lrg.jpg)